pentobarbital will improve the level or impact of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with strong CYP3A4 inducers diminished ivosidenib plasma concentrations.
This drug could improve the metabolism of estradiol when administered concurrently; sufferers on oral contraceptives became pregnant when concurrently dealt with with antiepileptic medication; counsel an alternate contraceptive strategy to women having this drug
pentobarbital will lower the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the extent or result of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Unknown.
pentobarbital will decrease the level or influence of donepezil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
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pentobarbital will lessen the level or effect of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration with robust or average CYP3A4 inducers is contraindicated.
pentobarbital will lessen the extent or result of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers may lead to diminished serum concentrations and lack of antimalarial efficacy
Contraindicated (1)pentobarbital will decrease the extent or effect of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls must not choose estradiol valerate/dienogest as their contraceptive even though applying powerful CYP3A4 inducers as a result of possible reduce in contraceptive efficacy.
pentobarbital will minimize the level or effect of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Strong or average CYP3A4 inducers drastically cut down guanfacine plasma concentrations and elimination half-daily life.
pentobarbital will decrease the level or influence of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the level or result of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Seine potenzsteigernde Wirkung wurde teilweise in Studien geprüft – nach modernen wissenschaftlichen Criteria gelten diese aber als qualitativ nicht ausreichend.